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Evaluation of the effects of ultraviolet rays and chemical mutagens using microorganisms and plants.

Keywords: mutagen, ultraviolet light, radiation, DNA repair, Escherichia coli, Aspergillus oryzae, Arabidopsis thaliana

DNA, which carries the genetic information of living organisms, is exposed to various DNA-damaging factors. DNA damage can induce genetic mutations, leading to cancer, genetic diseases, and cellular aging. To protect themselves from these threats, organisms have acquired DNA damage repair mechanisms. This mechanism is present in almost all living organisms on Earth, from E. coli to plants and humans, and each organism builds a DNA repair system suitable for its survival strategy. I am working to elucidate the full extent of the DNA damage repair mechanisms possessed by non-human organisms by conducting basic research on DNA damage repair, mutation induction, and cellular aging using higher plants and microorganisms. In the future, I hope to apply the insights gained from this basic research to promote the growth of useful organisms and reduce diseases caused by pathogenic microorganisms.

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